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PKD1, PKD2, PKHD1 Rodent Models (Biosensors, Reporters, and Cre Lines)
Mouse Biosensor and Reporter Lines
CiliaGFP: Expresses GFP-tagged SSTR3 in all cilia
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GCaMP6F Ca2+ Biosensor: Expresses a cytosolic Ca2+ reporter
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IRG Reporter: Expresses dsRed ubiquitously before Cre expression and GFP after recombination
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mTmG Reporter: Expresses dTomato ubiquitously before Cre expression and GFP after recombination
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R26tdTomato Reporter: Expresses tdTomato after Cre recombination
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Rosa26 LacZ Reporter: Expresses LacZ after Cre recombination
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Mouse Cre and Flp Lines
HoxB7-Cre: Expresses Cre in collecting ducts
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Rosa26-CreER: Ubiquitous expression of tamoxifen inducible Cre
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Rosa26-FlpoER: Ubiquitous expression of tamoxifen inducible Flp recombinase
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Rosa26-M2rtTA: Ubiquitous expression of tet-responsive rtTA
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Multi-Allele Mouse Lines
Pkd1 Flox; CAGG-CreERT2; Rosa26: Ubiquitous deletion of Pkd1 after Tamoxifen induction
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Pkd1 Flox; HoxB7-Cre: Deletion of Pkd1 in tubular segments derived from the ureteric bud
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Pkd1 Flox; KspCre: Distal and collecting duct specific deletion of Pkd1
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Pkd1 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd1 after Doxycycline induction with a fluorescent reporter
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Pkd1 Flox; Pax8-rtTA; tetO-7-Cre: Nephron specific deletion of Pkd1 after Doxycycline induction
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Pkd1 Flox; PKHD1-Cre: Collecting duct specific deletion of Pkd1
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Pkd1 Flox; Rosa26-CreER: Allows global deletion of Pkd1 via tamoxifen injection
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Pkd1flox; mTmG: Pkd1 conditional allele with a fluorescent reporter
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Pkd2 Flox; CAGG-CreERT2; Rosa26: Ubiquitous deletion of Pkd2 after Tamoxifen induction
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PKD2 Flox; CAGG-CreERT2: Ubiquitous deletion of Pkd2 after Tamoxifen induction
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Pkd2 Flox; GCaMP6F: Pkd2 conditional allele with a cytosolic Ca+2 reporter
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Pkd2 Flox; Ift88 Flox; CAGG-CreERT2: Simultaneous ubiquitous deletion of Pkd2 and Ift88 after Tamoxifen induction
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Pkd2 Flox; Ift88 Flox; mTmG: Pkd2 and Ift88 conditional alleles with a fluorescent reporter
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Pkd2 Flox; Ksp-Cre: Distal and collecting duct specific deletion of Pkd2
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Pkd2 Flox; mTmG: Pkd2 conditional allele with a fluorescent reporter
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Pkd2 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd2 after Doxycycline induction with a fluorescent reporter
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Pkd2 Flox; Pax8-rtTA; tetO-7-Cre: Nephron specific deletion of Pkd2 after Doxycycline induction
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Pkd2 Flox; Pkhd1-Cre: Collecting duct specific deletion of Pkd2
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Pkd2 Flox; Rosa26-CreER: Global deletion of Pkd2 after tamoxifen induction
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PKD1 Single Allele Strains Mouse Models
Pkd1 3xHA: Endogenously tagged Pkd1 allele
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Pkd1 deltaL: Pkd1 patient mutation L4122delta
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PKD1 flox: Pkd1 conditional allele
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Pkd1 Heterozygous: Pkd1 knock-out allele
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PKD1 N Delta L: Pkd1 C-terminal truncation allele
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Pkd1 V: Uncleavable Pkd1 hypomorhic allele
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PKD2 Single Allele Strains Mouse Models
Pkd2 Flox: Pkd2 conditional allele
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Pkd2 Heterozygous: Pkd2 knock-out allele
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Pkd2exon15Halo: PKD2 with endogenous Halo tag introduced at the PC2 C-terminus
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PKHD1 Single Allele Strains Mouse Models
Pkhd1 3xHA: Endogenously HA-tagged Pkhd1 model ARPKD
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Pkhd1 Delta 3-4: Pkhd1 mutant model ARPKD
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Pkhd1 Delta 67: Pkhd1 mutant model ARPKD
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PKHD1 Rat Models
PKHD1 (pck) Rat
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