Pkd1 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd1 after Doxycycline induction with a fluorescent reporter

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Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.

Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

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