Description: This transgenic mouse model allows widespread expression of an optimized form of reverse tetracycline-controlled transactivator (rtTA-M2) protein inserted downstream of ROSA promoter. This R26-M2rtTA strain may be useful for doxycycline-inducible studies which utilize rtTA/tet-O (tet-on/TRE) models. Homozygous and hemizygous mice are phenotypically normal.

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