Pkd2 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd2 after Doxycycline induction with a fluorescent reporter
Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.
Note: Additional combination of alleles can be performed upon request