Description: These mice strain carries the PKD1 Floxed allele crossed with a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal. Depending on the timing of tamoxifen induction this will lead to a either a rapidly or slowly progressing model of PKD.

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