PKD1 N Delta L: Pkd1 C-terminal truncation allele

Description: This knock-in mutant mouse model has a Neomycin targeting cassette disrupting splicing of exon 45 and a deletion of Leu 4122 in PKD1. The splice defect results in premature truncation of the mutant protein. Homozygous mice are embryonically lethal. Cre-mediated excision of the targeting cassette produces the PKD1 Delta L allele.


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