Archive for: In Vivo PKD Models and Reagents

NEW Pkd2D509V Missense mutation

NEW Pkd2exon15Halo: PKD2 with endogenous Halo tag introduced at the PC2 C-terminus

Pkd1 Flox; HoxB7-Cre: Deletion of Pkd1 in tubular segments derived from the ureteric bud

Pkd2 Flox; Rosa26-CreER: Global deletion of Pkd2 after tamoxifen induction

Pkd1 Flox; Rosa26-CreER: Allows global deletion of Pkd1 via tamoxifen injection

Ift88flox;GCaMP6F

Ift88flox;mTmG

Pkd2 Flox; Ift88 Flox; CAGG-CreERT2: Simultaneous ubiquitous deletion of Pkd2 and Ift88 after Tamoxifen induction

Ift88flox;CAGGCre-ER

Pkd2 Flox; Ift88 Flox; mTmG: Pkd2 and Ift88 conditional alleles with a fluorescent reporter

Pkd1 Flox; CAGG-CreERT2; Rosa26: Ubiquitous deletion of Pkd1 after Tamoxifen induction

Pkd1 Flox; KspCre: Distal and collecting duct specific deletion of Pkd1

Pkd1flox; mTmG: Pkd1 conditional allele with a fluorescent reporter

Pkd1 Flox; Pax8-rtTA; tetO-7-Cre: Nephron specific deletion of Pkd1 after Doxycycline induction

Pkd1 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd1 after Doxycycline induction with a fluorescent reporter

Pkd1 Flox; PKHD1-Cre: Collecting duct specific deletion of Pkd1

Pkd2 Flox; mTmG: Pkd2 conditional allele with a fluorescent reporter

PKD2 Flox; CAGG-CreERT2: Ubiquitous deletion of Pkd2 after Tamoxifen induction

Pkd2 Flox; GCaMP6F: Pkd2 conditional allele with a cytosolic Ca+2 reporter

Pkd2 Flox; CAGG-CreERT2; Rosa26: Ubiquitous deletion of Pkd2 after Tamoxifen induction

Pkd2 Flox; Ksp-Cre: Distal and collecting duct specific deletion of Pkd2

Pkd2 Flox; Pax8-rtTA; tetO-7-Cre: Nephron specific deletion of Pkd2 after Doxycycline induction

Pkd2 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd2 after Doxycycline induction with a fluorescent reporter

Pkd2 Flox; Pkhd1-Cre: Collecting duct specific deletion of Pkd2

NPHP14 Null

Rosa26 LacZ Reporter: Expresses LacZ after Cre recombination

Pkd1 deltaL: Pkd1 patient mutation L4122delta

Rosa26-M2rtTA: Ubiquitous expression of tet-responsive rtTA

Pkd1 3xHA: Endogenously tagged Pkd1 allele

Rosa26-FlpoER: Ubiquitous expression of tamoxifen inducible Flp recombinase

Ift88 Orpk FVB

R26tdTomato Reporter: Expresses tdTomato after Cre recombination

Nphp4 Truncation

Rosa26-CreER: Ubiquitous expression of tamoxifen inducible Cre

Nphp4 Allele 2

Pkhd1 3xHA: Endogenously HA-tagged Pkhd1 model ARPKD

Pkhd1 Delta 3-4: Pkhd1 mutant model ARPKD

Pkhd1 Delta 67: Pkhd1 mutant model ARPKD

Pkd2 Heterozygous: Pkd2 knock-out allele

Pkd2 Flox: Pkd2 conditional allele

Pkd1 V: Uncleavable Pkd1 hypomorhic allele

PKD1 N Delta L: Pkd1 C-terminal truncation allele

Pkd1 Heterozygous: Pkd1 knock-out allele

PKD1 flox: Pkd1 conditional allele

JBTS13 Null

Nphp4 Null

Nphp1 Allele 2

HoxB7-Cre: Expresses Cre in collecting ducts

Nphp1 Null

Ift172 Null