Rosa26 LacZ Reporter

Description: This mouse reporter line harbors a lox-P flanked neomycin cassette up-stream of a β-galactosidase (Lac-Z) sequence. These mice express Lac-Z following Cre-mediated recombination.
Contact: info@pkd-rrc.org

Rosa26-M2rtTA

Description: This transgenic mouse model allows widespread expression of an optimized form of reverse tetracycline-controlled transactivator (rtTA-M2) protein inserted downstream of ROSA promoter. This R26-M2rtTA strain may be useful for doxycycline-inducible studies which utilize rtTA/tet-O (tet-on/TRE) models. Homozygous and hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org

Rosa26-FlpoER

Description: This transgenic mouse model has a tamoxifen-inducible Cre-mediated recombination system driven by the chicken beta actin promoter and a tamoxifen-inducible FlpoER fusion protein inserted into the Gt(ROSA)26Sor locus, resulting in FLP recombination in all embryonic and adult tissues containing frt-flanked sequences. Homozygous and hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org

R26tdTomato Reporter

Description: This mouse reporter line harbors a lox-P flanked STOP cassette preventing transcription of a CAG promoter driven red fluorescent protein (tdTomato) in the Rosa26 locus. These mice express robust tdTomato fluorescence following Cre-mediated recombination.
Contact: info@pkd-rrc.org

mTmG Reporter

Description: This mouse reporter line harbors a double-fluorescent Cre reporter that widely expresses the membrane-targeted tandem dimer Tomato (mT) in all cells/tissue. After Cre recombination the red mT cassette is deleted and the membrane-targeted green fluorescent protein (mG) is expressed in the Cre targeted cells/tissue. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

IRG Reporter

Description: This mouse reporter line harbors a double-fluorescent Cre reporter allele with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following Cre-mediated recombination. The allele is functionally similar to mTmG, but does not reside in the Rosa26 locus. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

5HT6mCherry-IA-G-GECO Biosensor

Description: This knock-in mouse model expresses a transgene expressing 5HT6-mCherry-IA-G-GECO1.0 fusion protein and is a biosensor that measures Ca+2 changes in cilia throughout the mouse. These mice are phenotypically normal.

Contact: info@pkd-rrc.org

CAGG-CreERT2

Description: This transgenic mouse model has a tamoxifen-inducible Cre-mediated recombination system driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer. When bred with mice containing LoxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed alleles in widespread embryonic or adult cells/tissues. Homozygous mice are not viable or fertile. Hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org

CiliaGFP

Description: This knock-in mouse model carries a floxed STOP cassette upstream of a cilia-localized somatostatin receptor 3 (SSTR3) protein fused to GFP that results in a ubiquitous green fluorescent cilia after Cre recombination. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

GCaMP6F Ca2+ Biosensor

Description:This mouse model harbors a Rosa-CAG-LSL-GCaMP6f conditional allele, designed with a floxed-STOP cassette upstream of the GCaMP6 fast variant calcium sensor. After Cre recombination a bright EGFP cytosolic fluorescence is observed following calcium binding to the reporter. These mice are phenotypically normal.
Contact: info@pkd-rrc.org