(tetO)7-Cre

Description: This transgenic mouse model expresses Cre recombinase under the control of a tetracycline-responsive promoter element (TRE or tetO) and is an effective tool for inducible, tissue-specific studies. When bred with another transgenic mouse expressing the reverse tetracycline-controlled transactivator protein (rtTA) or tetracycline-controlled transactivator protein (tTA) the Cre mediated recombination is induced by doxycycline.
Contact: info@pkd-rrc.org

Rosa26-CreER

Description: These mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal.
Contact: info@pkd-rrc.org

Rosa26-FlpoER

Description: This transgenic mouse model has a tamoxifen-inducible Cre-mediated recombination system driven by the chicken beta actin promoter and a tamoxifen-inducible FlpoER fusion protein inserted into the Gt(ROSA)26Sor locus, resulting in FLP recombination in all embryonic and adult tissues containing frt-flanked sequences. Homozygous and hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org

Rosa26-M2rtTA

Description: This transgenic mouse model allows widespread expression of an optimized form of reverse tetracycline-controlled transactivator (rtTA-M2) protein inserted downstream of ROSA promoter. This R26-M2rtTA strain may be useful for doxycycline-inducible studies which utilize rtTA/tet-O (tet-on/TRE) models. Homozygous and hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org

HoxB7-Cre

Description: This transgenic mouse model expresses Cre recombinase under the control of the mouse HoxB7 promoter. The Cre recombinase expression is detected in collecting ducts of ureteric bud descendants.
Contact: info@pkd-rrc.org

Ksp-Cre

Description: This transgenic mouse model expresses Cre recombinase under the control of the mouse cadherin 16 (or Ksp1.3) promoter. Cre recombinase expression is detected in epithelial cells of the developing kidney and genitourinary tract and in distal tubules of the adult mice. Hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org

CAGG-CreERT2

Description: This transgenic mouse model has a tamoxifen-inducible Cre-mediated recombination system driven by the chicken beta actin promoter/enhancer coupled with the cytomegalovirus (CMV) immediate-early enhancer. When bred with mice containing LoxP-flanked sequences, tamoxifen-inducible Cre-mediated recombination results in deletion of the floxed alleles in widespread embryonic or adult cells/tissues. Homozygous mice are not viable or fertile. Hemizygous mice are phenotypically normal.

Contact: info@pkd-rrc.org