Description: These mice have a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal.
Contact: info@pkd-rrc.org
Description: This transgenic mouse model has a tamoxifen-inducible Cre-mediated recombination system driven by the chicken beta actin promoter and a tamoxifen-inducible FlpoER fusion protein inserted into the Gt(ROSA)26Sor locus, resulting in FLP recombination in all embryonic and adult tissues containing frt-flanked sequences. Homozygous and hemizygous mice are phenotypically normal.
Contact: info@pkd-rrc.org
Description: This transgenic mouse model allows widespread expression of an optimized form of reverse tetracycline-controlled transactivator (rtTA-M2) protein inserted downstream of ROSA promoter. This R26-M2rtTA strain may be useful for doxycycline-inducible studies which utilize rtTA/tet-O (tet-on/TRE) models. Homozygous and hemizygous mice are phenotypically normal.
Contact: info@pkd-rrc.org
Description: This transgenic mouse model expresses Cre recombinase under the control of the mouse HoxB7 promoter. The Cre recombinase expression is detected in collecting ducts of ureteric bud descendants.
Contact: info@pkd-rrc.org
