PKD2 Flox; Pax8-rtTA; tetO-7-Cre

Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre. This allows tetracycline/doxycycline induced deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney

Contact: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request

PKD2 Flox; Pax8-rtTA; tetO-7-Cre; mTmG

Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.

Contact
: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request

PKD2 Flox; Ift88 Flox; CAGG-CreERT2

Description: This strain carries both the PKD2 and Ift88 Floxed alleles crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion of both genes.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

PKD2 Flox; PKHD1-Cre

Description: This strain caries the PKD2 Floxed allele crossed with the PKDHd1 promoter that drives Cre expression predominantly in the collecting duct.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

PKD2 Flox; Ift88 Flox; mTmG

Description: This strain carries both the PKD2 and Ift88 Floxed alleles crossed with mTmG Cre reporter to detect Cre activity. Prior to Cre recombinase activation, the cells express mTomato. After Cre excision of mTomato, the cells express mGFP.
Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

PKD1 Flox; CAGG-CreERT2; Rosa26

Description: This strain carries the PKD1 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion, and the Rosa26 LacZ Cre reporter to detect Cre activity.

Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

PKD1flox; KspCre

Description: This strain has the Pkd1 Flox allele crossed with the Ksp (Cadherin 16) promoter driven Cre recombinase. Cre-mediated recombination is detected in the epithelium of the kidney, the genitourinary tract, and adult renal tubules especially the collecting ducts, loops of Henle and distal tubules.

Contact: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request

PKD1flox; mTmG

Description: This strain carries the PKD1 Floxed allele crossed with the mTmG Cre reporter. Prior to Cre-mediated recombination, there is expression of mTomato. After Cre mediated excision there is expression of mGFP.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

PKD1 Flox; Pax8-rtTA; tetO-7-Cre

Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre. This allows tetracycline/doxycycline induced deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

PKD1 Flox; Pax8-rtTA; tetO-7-Cre; mTmG

Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.

Contact
: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request

PKD1 Flox; PKHD1-Cre

Description: This strain carries the Pkd1 Floxed allele crossed with the Pkdhd1 promoter that drives Cre expression predominantly in the collecting duct.

Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

PKD2 Flox; mTmG

Description:This strain carries the PKD2 Floxed allele crossed with the mTmG Cre reporter. Prior to Cre-mediated recombination, there is expression of mTomato. After Cre mediated excision there is expression of mGFP.
Contact: pgarcia@som.umaryland.edu, pydnam@uab.edu
Note : Additional combination of alleles can be performed upon request

PKD2 Flox; 5HT6mCherry-IA-G-GECO

Description: This strain carries the PKD2 Floxed allele crossed with the 5HT6mCherry-IA-G-Geco ciliary targeted ratiometric Ca2+ biosensor to measure calcium changes in the cilium.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

PKD2 Flox; CAGG-CreERT2

Description: This strain carries the PKD2 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion of PKD2.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request.

PKD2 Flox; GCaMP6F

Description: This strain carries the PKD2 Flox allele crossed with the GCamp6F cytosolic targeted Ca2+ biosensor.
Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

PKD2 Flox; CAGG-CreERT2; Rosa26

Description: This strain carries the PKD2 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion, and the Rosa26 LacZ Cre reporter to detect Cre activity.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

PKD2 Flox; Ksp-Cre

Description: This strain has the PKD1 Flox allelle crossed with the Ksp (Cadherin 16) promoter driven Cre recombinase. Cre-mediated recombination is detected in the epithelium of the kidney, the genitourinnary tract, and adult renal tubules especially the collecting ducts, loops of Henle and distal tubules.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request