Description: These mice strain carries the PKD1 Floxed allele crossed with a transgenic mouse model expresses Cre recombinase under the control of the mouse HoxB7 promoter. The Cre recombinase expression is detected in collecting ducts of ureteric bud descendants.
Contact: info@pkd-rrc.org
Description: These mice strain carries the PKD2 Floxed allele crossed with a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal.
Contact: info@pkd-rrc.org
Description: These mice strain carries the PKD1 Floxed allele crossed with a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal. Depending on the timing of tamoxifen induction this will lead to a either a rapidly or slowly progressing model of PKD.
Contact: info@pkd-rrc.org
Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
Description: This strain caries the PKD2 Floxed allele crossed with the PKDHd1 promoter that drives Cre expression predominantly in the collecting duct.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request
Description: This strain carries both the PKD2 and Ift88 Floxed alleles crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion of both genes.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request
Description: This strain carries both the PKD2 and Ift88 Floxed alleles crossed with mTmG Cre reporter to detect Cre activity. Prior to Cre recombinase activation, the cells express mTomato. After Cre excision of mTomato, the cells express mGFP.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
Description: This strain carries the PKD1 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion, and the Rosa26 LacZ Cre reporter to detect Cre activity.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
Description: This strain has the Pkd1 Flox allele crossed with the Ksp (Cadherin 16) promoter driven Cre recombinase. Cre-mediated recombination is detected in the epithelium of the kidney, the genitourinary tract, and adult renal tubules especially the collecting ducts, loops of Henle and distal tubules.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request. Possible delay due to third party MTA requirement.
Description: This strain carries the PKD1 Floxed allele crossed with the mTmG Cre reporter. Prior to Cre-mediated recombination, there is expression of mTomato. After Cre mediated excision there is expression of mGFP.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request
Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre. This allows tetracycline/doxycycline induced deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request
Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
Description: This strain carries the Pkd1 Floxed allele crossed with the Pkhd1 promoter that drives Cre expression predominantly in the collecting duct.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
Description:This strain carries the PKD2 Floxed allele crossed with the mTmG Cre reporter. Prior to Cre-mediated recombination, there is expression of mTomato. After Cre mediated excision there is expression of mGFP.
Contact: pgarcia@som.umaryland.edu, pydnam@uab.edu
Note : Additional combination of alleles can be performed upon request
Description: This strain carries the PKD2 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion of PKD2.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request.
Description: This strain carries the PKD2 Flox allele crossed with the GCamp6F cytosolic targeted Ca2+ biosensor.
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
Description: This strain carries the PKD2 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion, and the Rosa26 LacZ Cre reporter to detect Cre activity.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request
Description: This strain has the PKD1 Flox allelle crossed with the Ksp (Cadherin 16) promoter driven Cre recombinase. Cre-mediated recombination is detected in the epithelium of the kidney, the genitourinnary tract, and adult renal tubules especially the collecting ducts, loops of Henle and distal tubules.
Contact: info@pkd-rrc.org
Note : Additional combination of alleles can be performed upon request. Possible delay due to third party MTA requirement.
Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre. This allows tetracycline/doxycycline induced deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney
Contact: info@pkd-rrc.org
Note: Additional combination of alleles can be performed upon request
