Pkd1 Flox; HoxB7-Cre: Deletion of Pkd1 in tubular segments derived from the ureteric bud

Description: These mice strain carries the PKD1 Floxed allele crossed with a transgenic mouse model expresses Cre recombinase under the control of the mouse HoxB7 promoter. The Cre recombinase expression is detected in collecting ducts of ureteric bud descendants.

Contact: info@pkd-rrc.org

Pkd2 Flox; Rosa26-CreER: Global deletion of Pkd2 after tamoxifen induction

Description: These mice strain carries the PKD2 Floxed allele crossed with a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal.

Contact: info@pkd-rrc.org

Pkd1 Flox; Rosa26-CreER: Allows global deletion of Pkd1 via tamoxifen injection

Description: These mice strain carries the PKD1 Floxed allele crossed with a tamoxifen-inducible Cre-mediated recombination system driven by the endogenous mouse Gt(ROSA)26Sor promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, this mutant is useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Homozygous mice are viable and fertile and phenotypically normal. Depending on the timing of tamoxifen induction this will lead to a either a rapidly or slowly progressing model of PKD.

Contact: info@pkd-rrc.org

Pkd2 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd2 after Doxycycline induction with a fluorescent reporter

Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.

Contact
: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request

Pkd2 Flox; Pkhd1-Cre: Collecting duct specific deletion of Pkd2

Description: This strain caries the PKD2 Floxed allele crossed with the PKDHd1 promoter that drives Cre expression predominantly in the collecting duct.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

Pkd2 Flox; Ift88 Flox; CAGG-CreERT2

Description: This strain carries both the PKD2 and Ift88 Floxed alleles crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion of both genes.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

Pkd2 Flox; Ift88 Flox; mTmG

Description: This strain carries both the PKD2 and Ift88 Floxed alleles crossed with mTmG Cre reporter to detect Cre activity. Prior to Cre recombinase activation, the cells express mTomato. After Cre excision of mTomato, the cells express mGFP.
Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

Pkd1 Flox; CAGG-CreERT2; Rosa26: Ubiquitous deletion of Pkd1 after Tamoxifen induction

Description: This strain carries the PKD1 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion, and the Rosa26 LacZ Cre reporter to detect Cre activity.

Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

Pkd1 Flox; KspCre: Distal and collecting duct specific deletion of Pkd1

Description: This strain has the Pkd1 Flox allele crossed with the Ksp (Cadherin 16) promoter driven Cre recombinase. Cre-mediated recombination is detected in the epithelium of the kidney, the genitourinary tract, and adult renal tubules especially the collecting ducts, loops of Henle and distal tubules.

Contact: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request. Possible delay due to third party MTA requirement.

Pkd1flox; mTmG: Pkd1 conditional allele with a fluorescent reporter

Description: This strain carries the PKD1 Floxed allele crossed with the mTmG Cre reporter. Prior to Cre-mediated recombination, there is expression of mTomato. After Cre mediated excision there is expression of mGFP.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

Pkd1 Flox; Pax8-rtTA; tetO-7-Cre: Nephron specific deletion of Pkd1 after Doxycycline induction

Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre. This allows tetracycline/doxycycline induced deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

Pkd1 Flox; Pax8-rtTA; tetO-7-Cre; mTmG: Nephron specific deletion of Pkd1 after Doxycycline induction with a fluorescent reporter

Description: This strain caries the PKD1 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre and the mTmG Cre reporter. Treatment with tetracycline/doxycycline induces deletion of PKD1 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney. Cre-recombinase activity is reflected by a switch from expression of mTomato prior to mGFP.

Contact
: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request

Pkd1 Flox; PKHD1-Cre: Collecting duct specific deletion of Pkd1

Description: This strain carries the Pkd1 Floxed allele crossed with the Pkhd1 promoter that drives Cre expression predominantly in the collecting duct.

Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

Pkd2 Flox; mTmG: Pkd2 conditional allele with a fluorescent reporter

Description:This strain carries the PKD2 Floxed allele crossed with the mTmG Cre reporter. Prior to Cre-mediated recombination, there is expression of mTomato. After Cre mediated excision there is expression of mGFP.
Contact: pgarcia@som.umaryland.edu, pydnam@uab.edu
Note : Additional combination of alleles can be performed upon request

PKD2 Flox; CAGG-CreERT2

Description: This strain carries the PKD2 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion of PKD2.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request.

Pkd2 Flox; GCaMP6F

Description: This strain carries the PKD2 Flox allele crossed with the GCamp6F cytosolic targeted Ca2+ biosensor.
Contact: info@pkd-rrc.org

Note: Additional combination of alleles can be performed upon request

Pkd2 Flox; CAGG-CreERT2; Rosa26: Ubiquitous deletion of Pkd2 after Tamoxifen induction

Description: This strain carries the PKD2 Floxed allele crossed with CAGG-CreERT2 for systemic tamoxifen inducible deletion, and the Rosa26 LacZ Cre reporter to detect Cre activity.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request

Pkd2 Flox; Ksp-Cre: Distal and collecting duct specific deletion of Pkd2

Description: This strain has the PKD1 Flox allelle crossed with the Ksp (Cadherin 16) promoter driven Cre recombinase. Cre-mediated recombination is detected in the epithelium of the kidney, the genitourinnary tract, and adult renal tubules especially the collecting ducts, loops of Henle and distal tubules.
Contact: info@pkd-rrc.org

Note : Additional combination of alleles can be performed upon request. Possible delay due to third party MTA requirement.

Pkd2 Flox; Pax8-rtTA; tetO-7-Cre: Nephron specific deletion of Pkd2 after Doxycycline induction

Description: This strain caries the PKD2 Floxed allele crossed with Pax8-rtTA; tetO-7-Cre. This allows tetracycline/doxycycline induced deletion of PKD2 in the proximal and distal tubules and the collecting duct system of both embryonic and adult kidney

Contact: info@pkd-rrc.org

Note
: Additional combination of alleles can be performed upon request