Ift88flox;GCaMP6F

Contact: pydnam@uab.edu
Note: Additional combinations of alleles are available upon request

Ift88flox;mTmG

Contact: pydnam@uab.edu
Note: Additional combinations of alleles are available upon request

Ift88flox;CAGGCre-ER

Contact: pydnam@uab.edu
Note: Additional combinations of alleles are available upon request

Ift88 Orpk FVB

Description: This mouse model harbors a transgene that deletes 2.7kb of intron 23 in the Ift88 gene resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice in the FVB background develop multiple embryonic defects including preaxial polydactyly, hydrocephalus and cystic kidneys and can survive to 7-21 days of age.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Nphp4 Truncation

Description: This mouse model carry an ENU-induced mutation in the Nphp4 gene. Heterozygous mice are phenotypically normal. Homozygous mice develop a severe photoreceptor degeneration in the eye, oligozoospermia and asthenozoospermia.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Nek8 or jck

Description: This mouse model harbors a double nucleotide substitution in the Nek8 gene. Heterozygous mice are phenotypically normal. Homozygous mice develop cysts in the kidney at approximately 21 days after birth and die at 4 months of age.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Ift27 LacZ Null

Description: This mouse model carries a lacZ cassette and a Neomycin gene inserted in the second intron of the Ift27 gene. This allele expresses LacZ under the endogenous Ift27 promoter resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice are embryonic lethal.

Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Ift88 flox

Description: This conditional floxed mouse model harbors LoxP sites flanking exons 4 through 6 of the Ift88 gene. Homozygous mice are phenotypically normal. When bred with a Cre recombinase mouse line, offspring lack expression of Ift88 in the Cre targeted tissue. This mouse model may be useful to study human genetic ciliopathies.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Mksr1 (B9d1) Flox

Description: This conditional Mksr1 (B9d1) floxed mouse model harbors LoxP sites flanking exon 3 of the Mksr1 gene. Homozygous mice are phenotypically normal. When bred with a Cre recombinase mouse line, offspring lack expression of Mksr1 in the Cre targeted tissue.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Bbs5 flox

Description: This conditional Bbs5 floxed mouse model harbors LoxP sites flanking exons 3 through 4. Homozygous mice are phenotypically normal. When bred with a Cre recombinase mouse line, offspring lack expression of Bbs5 in the Cre targeted tissue.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Bbs5 LacZ

Description: This mouse model carries a lacZ cassette and a Neomycin gene inserted in intron 2 of the Bbs5 gene that disrupts expression of the Bbs5 protein. Heterozygous mice are phenotypically normal. Homozygous mice develop retinal defects and obesity.
Contact:info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Mks6 LacZ Null

Description: This mouse model carries a lacZ cassette and a Neomycin gene inserted in intron 5 of the Mks6 (Cc2d2a) gene that disrupts expression of the Mks6 protein.
Contact:info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Ift38 LacZ (Cluap1) Null

Description: This mouse model carries a lacZ: Neomycin fusion cassette inserted in intron 2 and LoxP sites flanking exon 3 of the Ift38 gene (aka Cluap1) resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice are embryonic lethal.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

cpk Heterozygous

Description: This knock-out mouse model has a spontaneous tandem deletion of 12 bp and 19 bp in the cpk gene that results in a frameshift mutation within exon 1, truncating cystin, the protein encoded by the cpk gene. Heterozygous mice are phenotypically normal. Homozygous mice develop rapidly progressive renal cystic disease that closely resembles human autosomal recessive PKD (ARPKD) and die by 3-4 weeks of age. C57Bl6 lack the intrahepatic biliary duct dilatation observed in different backgrounds.
Contact: pydnam@uab.edu
Note: Additional combinations of alleles are available upon request

Mksr1 LacZ (B9d1) Null

Description: This mouse model carries a lacZ cassette and a Neomycin gene inserted in intron 2 of the Mksr1 (B9d1) gene that disrupts expression of the Mksr1 protein.
Contact:info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Ift140 LacZ Null

Description: This mouse model carries a LacZ knock-in (null) allele of Ift140. Ift140 is a component of the IFT complex A, which results in shortened, bulging cilia when mutated.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request