Description: This mouse model harbors a transgene that deletes 2.7kb of intron 23 in the Ift88 gene resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice in the Balb/c background develop multiple embryonic defects including preaxial polydactyly, hydrocephalus and cystic kidneys and can survive 3-6 months of age.
Contact: info@pkd-rrc.org
Description: This mouse model harbors a transgene that deletes 2.7kb of intron 23 in the Ift88 gene resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice in the C57Bl/6 background develop multiple embryonic defects including preaxial polydactyly, hydrocephalus and cystic kidneys and can survive 2-4 months of age.
Contact: info@pkd-rrc.org
Description: This mouse model harbors a transgene that deletes 2.7kb of intron 23 in the Ift88 gene resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice in the FVB background develop multiple embryonic defects including preaxial polydactyly, hydrocephalus and cystic kidneys and can survive to 7-21 days of age.
Contact: info@pkd-rrc.org
Note: Additional combinations of alleles are available upon request
Description: This conditional floxed mouse model harbors LoxP sites flanking exons 4 through 6 of the Ift88 gene. Homozygous mice are phenotypically normal. When bred with a Cre recombinase mouse line, offspring lack expression of Ift88 in the Cre targeted tissue. This mouse model may be useful to study human genetic ciliopathies.
Contact: info@pkd-rrc.org
Note: Additional combinations of alleles are available upon request
Description: This mouse model carries a lacZ cassette and a Neomycin gene inserted in the second intron of the Ift27 gene. This allele expresses LacZ under the endogenous Ift27 promoter resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice are embryonic lethal.
Contact: info@pkd-rrc.org
Note: Additional combinations of alleles are available upon request
Description: This mouse model carries a lacZ: Neomycin fusion cassette inserted in intron 2 and LoxP sites flanking exon 3 of the Ift38 gene (aka Cluap1) resulting in a null allele. Heterozygous mice are phenotypically normal. Homozygous mice are embryonic lethal.
Contact: info@pkd-rrc.org
Note: Additional combinations of alleles are available upon request
Description: This mouse model carries a LacZ knock-in (null) allele of Ift140. Ift140 is a component of the IFT complex A, which results in shortened, bulging cilia when mutated.
Contact: info@pkd-rrc.org
Note: Additional combinations of alleles are available upon request
