Nphp4 Truncation

Description: This mouse model carry an ENU-induced mutation in the Nphp4 gene. Heterozygous mice are phenotypically normal. Homozygous mice develop a severe photoreceptor degeneration in the eye, oligozoospermia and asthenozoospermia.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Nek8 or jck

Description: This mouse model harbors a double nucleotide substitution in the Nek8 gene. Heterozygous mice are phenotypically normal. Homozygous mice develop cysts in the kidney at approximately 21 days after birth and die at 4 months of age.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Mksr1 (B9d1) Flox

Description: This conditional Mksr1 (B9d1) floxed mouse model harbors LoxP sites flanking exon 3 of the Mksr1 gene. Homozygous mice are phenotypically normal. When bred with a Cre recombinase mouse line, offspring lack expression of Mksr1 in the Cre targeted tissue.
Contact: info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request

Mksr1 LacZ (B9d1) Null

Description: This mouse model carries a lacZ cassette and a Neomycin gene inserted in intron 2 of the Mksr1 (B9d1) gene that disrupts expression of the Mksr1 protein.
Contact:info@pkd-rrc.org

Note: Additional combinations of alleles are available upon request