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2022 Symposium Recordings

Please click on the session title to view the recording.

Day One Session 1: Novel Aspects of Polycystin Function and Signaling

The Energetic Landscape of Opening the Polycystin Pore. Paul DeCaen, Ph.D., Assistant Professor, Northwestern University

Lessons from the Adhesion GPCR field for PKDs. Demet Araç, Ph.D., Associate Professor, The University of Chicago

Blood Pressure Regulation by Vascular Polycystin Proteins. Jonathan Jaggar, Ph.D., Professor, The University of Tennessee Health Science Center

Day One Session 2: Latest Advances in Pediatric Polycystic Kidney Disease (PKD)

ARPKD: Natural History Insights from the ARegPKD Study. Max Liebau, M.D., Head of Translational Pediatric Nephrology, University of Cologne

New Therapeutic Concepts Form Nephronophthisis and Related Ciliopathies. Sophie Saunier, Ph.D., Head of the Laboratory of Hereditary Kidney Diseases, IMAGINE Institute in Paris

Advancing in the Research of Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD). Djalila Mekahli, M.D., Ph.D., Professor, UZ Leuven, Belgium

Trainee Short Communications 

(Click on trainees name for the full abstract)

Navin Gupta, et al. “Human Organoid-on-a-Chip Model for Therapeutic Development in ARPKD”

Yu Ishimoto, et al. “A Novel Organoid Model for Autosomal Dominant Polycystic Kidney Disease Based on Mouse Nephron Progenitor Cells (NPCs)”

Thomas Naert, et al. “Xenopus Animal Models for Autosomal Polycystic Kidney Disease with Automated Deep Learning Analysis of Cystogenesis”

Inna Nikonorova, et al. “Identification of Novel Polycystin-Associated Cargo of Extracellular Vesicles (EVs) in Caenorhabditis elegans”

Cynthia J. Sieben, et al. “Comparative PKD1 and PKD2 Missense Variant Profiling Aids Molecular Diagnoses Across the ADPKD Spectrum and Reveals Common Pathomechanisms ”

Technology Session: -Omics, Finding a Needle in a Haystack

Defining Cellular Complexity in Human Autosomal Dominant Polycystic Kidney Disease by Multimodal Single Cell Analysis. Benjamin Humphreys, M.D., Ph.D., Professor, Washington University in St. Louis

Reconciling Sample Size and Accuracy in Genetic Studies for Kidney Disease. Simone Sanna-Cherchi, M.D., Associate Professor, Columbia University

Community Feedback – Critical Needs

(Click on each breakout room to view recording)

Breakout 1: In Vitro Models, Chairs: Darren Wallace and Paul Welling

Breakout 2: Animal Models, Chairs: CJ Haycraft and Patricia Outeda Garcia

Breakout 3: Clinical Resources, Chairs: Steve Seliger and Alan Yu

Day Two Session 1: Cool New Tools

PKD1 mRNA Cis-Inhibition in ADPKD. Vishal Patel, M.D., Associate Professor, The University of Texas Southwestern Medical Center

Delivering Insights into Organ Homeostasis and Regeneration Through In-Vivo Genome-Wide Screens. Kristin Knouse, M.D., Ph.D., Assistant Professor, Massachusetts Institute of Technology

Peptide-Based Micelles for PKD. Eun Ji Chung, Ph.D., Associate Professor, University of Southern California

Day Two Session 2: Hot Takes in Energy Utilization

Listening in on the Conversation Between Polycystins and Mitochondria. Michael Caplan, M.D., Ph.D., Professor, Yale School of Medicine

Harnessing NAD+ to Restore Energy Metabolism in AKI. Samir Parikh, M.D., Professor, The University of Texas Southwestern Medical Center

Trainee Workshop: Meet with Successful Young Investigators

Panel members:

Christine Maric-Bilkan, Ph.D., Program Director, NIDDK

Katharina Hopp, Ph.D., Assistant Professor, University of Colorado

Ronak Lakhia, M.D., Assistant Professor, UT Southwestern

Kurt Zimmerman, Ph.D., Assistant Professor, University of Oklahoma Health Sciences Center