2022 Symposium Recordings
Please click on the session title to view the recording.
Day One Session 1: Novel Aspects of Polycystin Function and Signaling
The Energetic Landscape of Opening the Polycystin Pore. Paul DeCaen, Ph.D., Assistant Professor, Northwestern University
Lessons from the Adhesion GPCR field for PKDs. Demet Araç, Ph.D., Associate Professor, The University of Chicago
Blood Pressure Regulation by Vascular Polycystin Proteins. Jonathan Jaggar, Ph.D., Professor, The University of Tennessee Health Science Center
Day One Session 2: Latest Advances in Pediatric Polycystic Kidney Disease (PKD)
ARPKD: Natural History Insights from the ARegPKD Study. Max Liebau, M.D., Head of Translational Pediatric Nephrology, University of Cologne
New Therapeutic Concepts Form Nephronophthisis and Related Ciliopathies. Sophie Saunier, Ph.D., Head of the Laboratory of Hereditary Kidney Diseases, IMAGINE Institute in Paris
Advancing in the Research of Pediatric Autosomal Dominant Polycystic Kidney Disease (ADPKD). Djalila Mekahli, M.D., Ph.D., Professor, UZ Leuven, Belgium
Trainee Short Communications
(Click on trainees name for the full abstract)
Navin Gupta, et al. “Human Organoid-on-a-Chip Model for Therapeutic Development in ARPKD”
Yu Ishimoto, et al. “A Novel Organoid Model for Autosomal Dominant Polycystic Kidney Disease Based on Mouse Nephron Progenitor Cells (NPCs)”
Thomas Naert, et al. “Xenopus Animal Models for Autosomal Polycystic Kidney Disease with Automated Deep Learning Analysis of Cystogenesis”
Inna Nikonorova, et al. “Identification of Novel Polycystin-Associated Cargo of Extracellular Vesicles (EVs) in Caenorhabditis elegans”
Cynthia J. Sieben, et al. “Comparative PKD1 and PKD2 Missense Variant Profiling Aids Molecular Diagnoses Across the ADPKD Spectrum and Reveals Common Pathomechanisms ”
Technology Session: -Omics, Finding a Needle in a Haystack
Defining Cellular Complexity in Human Autosomal Dominant Polycystic Kidney Disease by Multimodal Single Cell Analysis. Benjamin Humphreys, M.D., Ph.D., Professor, Washington University in St. Louis
Reconciling Sample Size and Accuracy in Genetic Studies for Kidney Disease. Simone Sanna-Cherchi, M.D., Associate Professor, Columbia University
Community Feedback – Critical Needs
(Click on each breakout room to view recording)
Breakout 1: In Vitro Models, Chairs: Darren Wallace and Paul Welling
Breakout 2: Animal Models, Chairs: CJ Haycraft and Patricia Outeda Garcia
Breakout 3: Clinical Resources, Chairs: Steve Seliger and Alan Yu
Day Two Session 1: Cool New Tools
PKD1 mRNA Cis-Inhibition in ADPKD. Vishal Patel, M.D., Associate Professor, The University of Texas Southwestern Medical Center
Delivering Insights into Organ Homeostasis and Regeneration Through In-Vivo Genome-Wide Screens. Kristin Knouse, M.D., Ph.D., Assistant Professor, Massachusetts Institute of Technology
Peptide-Based Micelles for PKD. Eun Ji Chung, Ph.D., Associate Professor, University of Southern California
Day Two Session 2: Hot Takes in Energy Utilization
Listening in on the Conversation Between Polycystins and Mitochondria. Michael Caplan, M.D., Ph.D., Professor, Yale School of Medicine
Harnessing NAD+ to Restore Energy Metabolism in AKI. Samir Parikh, M.D., Professor, The University of Texas Southwestern Medical Center
Trainee Workshop: Meet with Successful Young Investigators
Panel members:
Christine Maric-Bilkan, Ph.D., Program Director, NIDDK
Katharina Hopp, Ph.D., Assistant Professor, University of Colorado
Ronak Lakhia, M.D., Assistant Professor, UT Southwestern
Kurt Zimmerman, Ph.D., Assistant Professor, University of Oklahoma Health Sciences Center
