Valencia, T., Yen, L. Y., Berman, C., Vincent, T., Davis, S., Varrone, F., Huang, J., Mastroianni, J., Carlson, M., Owen, T., Kamel, A., Drygin, D., Kinberger, G. A., Gangwar, S. P., Yelshanskaya, M. V., Ridley, J., Kirby, R., Alvarez, J., Lakhia, R., ... Lee, E. C. (2026). The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity. Nature Communications. DOI: https://doi.org/10.1038/s41467-025-65799-5 [Article] [DOI]