Valencia T, Yen LY, Berman C, Vincent T, Davis S, Varrone F, Huang J, Mastroianni J, Carlson M, Owen T, Kamel A, Drygin D, Kinberger GA, Gangwar SP, Yelshanskaya MV, Ridley J, Kirby R, Alvarez J, Lakhia R, Patel V, Sobolevsky AI, Lee EC. (2026). The nucleobase guanine at the 3′-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicity. Nat Commun. 2025 Nov 28;16(1):10762. doi: 10.1038/s41467-025-65799-5. PMID: 41315228; PMCID: PMC12663328. DOI: 10.1038/s41467-025-65799-5 [Article] [DOI]