Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine

Akakpo JY, Ramachandran A, Rumack BH, Wallace DP, Jaeschke H. (2023). Lack of mitochondrial Cyp2E1 drives acetaminophen-induced ER stress-mediated apoptosis in mouse and human kidneys: Inhibition by 4-methylpyrazole but not N-acetylcysteine. Toxicology. 2023 Dec;500:153692 DOI: 10.1016/j.tox.2023.153692 [Article] [DOI]