R26tdTomato Reporter

Description: This mouse reporter line harbors a lox-P flanked STOP cassette preventing transcription of a CAG promoter driven red fluorescent protein (tdTomato) in the Rosa26 locus. These mice express robust tdTomato fluorescence following Cre-mediated recombination.
Contact: info@pkd-rrc.org

Rosa26 LacZ Reporter

Description: This mouse reporter line harbors a lox-P flanked neomycin cassette up-stream of a β-galactosidase (Lac-Z) sequence. These mice express Lac-Z following Cre-mediated recombination.
Contact: info@pkd-rrc.org

IRG Reporter

Description: This mouse reporter line harbors a double-fluorescent Cre reporter allele with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following Cre-mediated recombination. The allele is functionally similar to mTmG, but does not reside in the Rosa26 locus. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

mTmG Reporter

Description: This mouse reporter line harbors a double-fluorescent Cre reporter that widely expresses the membrane-targeted tandem dimer Tomato (mT) in all cells/tissue. After Cre recombination the red mT cassette is deleted and the membrane-targeted green fluorescent protein (mG) is expressed in the Cre targeted cells/tissue. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

CiliaGFP

Description: This knock-in mouse model carries a floxed STOP cassette upstream of a cilia-localized somatostatin receptor 3 (SSTR3) protein fused to GFP that results in a ubiquitous green fluorescent cilia after Cre recombination. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

GCaMP6F Ca2+ Biosensor

Description:This mouse model harbors a Rosa-CAG-LSL-GCaMP6f conditional allele, designed with a floxed-STOP cassette upstream of the GCaMP6 fast variant calcium sensor. After Cre recombination a bright EGFP cytosolic fluorescence is observed following calcium binding to the reporter. These mice are phenotypically normal.
Contact: info@pkd-rrc.org

5HT6mCherry-IA-G-GECO Biosensor

Description: This knock-in mouse model expresses a transgene expressing 5HT6-mCherry-IA-G-GECO1.0 fusion protein and is a biosensor that measures Ca+2 changes in cilia throughout the mouse. These mice are phenotypically normal.

Contact: info@pkd-rrc.org