Custom Mouse and Zebrafish Models

  • Null and Specific Homology Driven Repair Missense Mouse or Rat mutations in PKD genes using CRISPR/Cas9
  • Null and Specific Homology Driven Repair Missense Zebrafish Mutations in PKD genes using CRISPR/Cas9
  • Other gene targeting (eg Flox conditional alleles, bioreporter lines targeting to the Rosa26 locus or Myh9 intron) projects available on request

Please request a consultation with the PKD RRC Core Directors at info@pkd-rrc.org

After discussing the project with the PKD RRC, a quotation outlining the costs of model generation will be provided.

Custom Pre-clinical Trial Design

  • Pre-clinical trials of novel therapeutic compounds using PKD1 and PKD2 inducible models, PKD1v/v mouse model and PCK rat model
  • MRI imaging available
  • We can provide advice on the design and conduct of pre-clinical studies
  • We can conduct a preclinical trial for you
  • Review the models that are available (link to PDF file)

Please request a consultation with the PKD RRC Core Directors at info@pkd-rrc.org

After discussing the project with the PKD RRC, a quotation outlining the costs of model generation will be provided.